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Caution should be exercised when administering SYNTHROID to patients with underlying cardiovascular diseaseto the elderlyand to those with concomitant adrenal insufficiencysee PRECAUTIONS

Many other medicines can be affected by your thyroid hormone levelsCertain other medicines may also increase or decrease the effects of levothyroxine.

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SYNTHROID is administered as a single daily dosepreferably one-half to one-hour before breakfastSYNTHROID should be taken at least 4 hours apart from drugs that are known to interfere with its absorptionsee DRUG INTERACTIONS

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