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Do not cut, crush, or chew the prograf capsule make sure that you receive the same tacrolimus medicine every time you collect your prescription, unless your transplant specialist has agreed to change to a different tacrolimus medicine.

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Some people taking Prograf after a kidney transplant have developed diabetesThis effect has been seen most commonly in people who are Hispanic or African-AmericanTalk with your doctor about your individual risk of diabetes if you have concerns.

ISMP Canada reviewed 33 medication incidents involving these drugs that have been reported internationallyIn most of these incidentsthe mix-up between Prograf and Advagraf occurred during prescribing and/or dispensingThe following common themes were identified from these error reports:

Low magnesium or phosphatebone painjerky muscle movementsmuscle weakness or limp feelingslow reflexes;

Tacrolimus may cause a condition that affects the heart rhythmQT prolongationQT prolongation can rarely cause seriousrarely fatalfast/irregular heartbeat and other symptomssuch as severe dizzinessfaintingthat need medical attention right away.

Shakingheadachediarrheanausea/vomitingupset stomachloss of appetitetrouble sleepingand tingling of the hands/feet may occurIf any of these effects persist or worsentell your doctor or pharmacist promptly.

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