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Antiarrhythmics eg, propafenone, flecainide , beta-blockers eg, metoprolol , phenothiazines eg, thioridazine , selective serotonin reuptake inhibitor ssri antidepressants eg, fluoxetine , or tricyclic antidepressants eg, nortriptyline since the risk of their unwanted effects could be increased by zyban sustained-release tablets.
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Metoprolol is a beta 1selectivecardioselectiveadrenergic receptor blocking agentThis preferential effect is not absolutehoweverand at higher plasma concentrationsmetoprolol also inhibits beta 2adrenoreceptorschiefly located in the bronchial and vascular musculatureMetoprolol has no intrinsic sympathomimetic activityand membrane-stabilizing activity is detectable only at plasma concentrations much greater than required for beta-blockadeAnimal and human experiments indicate that metoprolol slows the sinus rate and decreases AV nodal conduction.
The dose needs to be reduced slowly over 7 to 14 days to make sure that your condition does not get worseYour doctor will buy depakote, buy clomid. tell you how to gradually reduce the dose before stopping completely.
Catecholamine depleting drugse.greserpinemonoamine oxidaseMAOinhibitorsmay have an additive effect when given with beta-blocking agentsObserve patients treated with TOPROL-XL plus a catecholamine depletor for evidence of hypotension or marked bradycardiawhich may produce vertigosyncopeor postural hypotension.
Do not crush or chew extended-release capsules or tabletsDoing so can release all of the drug at onceincreasing the risk of side effects.
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