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Premarin is indicated as replacement therapy for oestrogen deficiency states associated with climacteric manifested by moderate to severe vasomotor symptoms associated with the oestrogen deficiency in natural and surgical menopause sweating, hot flushes .

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Avoid smokingIt can greatly increase your risk of blood clotsstrokeor heart attack while using conjugated estrogens.

Retinal vascular thrombosis has been reported in patients receiving estrogensDiscontinue medication pending examination if there is sudden partial or complete loss of visionor a sudden onset of proptosisdiplopiaor migraineIf examination reveals papilledema or retinal vascular lesionsestrogens should be permanently discontinued.

Epidemiological evidence from a large meta-analysis suggests a slightly increased risk in women taking estrogen-only or combined estrogen-progestogen HRTwhich becomes apparent within 5 years of use and diminishes over time after stopping.

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premarin tablets also contain the following inactive ingredients calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, and titanium dioxide.