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The use of azathioprine for inhibition of renal homograft rejection is well establishedthe mechanism(sfor this action are somewhat obscureThe drug suppresses hypersensitivities of the cell-mediated type and causes variable alterations in antibody productionSuppression of T-cell effectsincluding ablation of T-cell suppressionis dependent on the temporal relationship to antigenic stimulus or engraftmentThis agent has little effect on established graft rejections or secondary responses.
As there is in vitro evidence that buy sildenafil, buy clomid. aminosalicyclate derivatives(egolsalazinemesalazine or sulphasalazineinhibit the TPMT enzymethey should be administered with caution to patients receiving concurrent Imuran therapysee 4.4 Special Warning and Special Precautions for Use
Alterations in specific immune responses or immunologic functions in transplant recipients are difficult to relate specifically to immunosuppression by azathioprineThese patients have subnormal responses to vaccineslow numbers of T-cellsand abnormal phagocytosis by peripheral blood cellsbut their mitogenic responsesserum immunoglobulinsand secondary antibody responses are usually normal.
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