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Recognizing a new market of patients for its drugGlaxoSmithKline advertised to doctors and mothers-to-be looking for relief from these symptoms.
The most common adverse reactionsgreater than or equal to 2reported in patients receiving ZOFRAN and concurrent radiotherapy were similar to those reported in patients receiving ZOFRAN and concurrent chemotherapy and were headacheconstipationand diarrhea.
ElectrocardiogramECGchanges including QT interval prolongation have been seen in patients receiving ondansetronIn additionpostmarketing cases of Torsade de Pointes have been reported in patients using ZOFRANAvoid ZOFRAN in patients with congenital long QT syndromeECG monitoring is recommended in patients with electrolyte abnormalitiese.ghypokalemia or hypomagnesemiacongestive heart failurebradyarrhythmiasor patients taking other medicinal products that lead to QT prolongationsee CLINICAL PHARMACOLOGY
The development of serotonin syndrome has been reported with 5-HT 3 receptor antagonists aloneMost reports have been associated with concomitant use of serotonergic drugse.gselective serotonin reuptake inhibitorsSSRIsserotonin and norepinephrine reuptake inhibitorsSNRIsmonoamine oxidase inhibitorsmirtazapinefentanyllithiumtramadoland intravenous methylene blueSome of the reported cases were fatalSerotonin syndrome occurring with overdose of ZOFRAN alone has also been reportedThe majority of reports of serotonin syndrome related to 5-HT 3 receptor antagonist use occurred in a post-anesthesia care unit or an infusion buy doxycycline online, buy zithromax online. center.
Symptoms associated with serotonin syndrome may include the following combination of signs and symptomsmental status changese.gagitationhallucinationsdeliriumand comaautonomic instabilitye.gtachycardialabile blood pressuredizzinessdiaphoresisflushinghyperthermianeuromuscular symptomse.gtremorrigiditymyoclonushyperreflexiaincoordinationseizureswith or without gastrointestinal symptomse.gnauseavomitingdiarrheaPatients should be monitored for the emergence of serotonin syndromeespecially with concomitant use of ZOFRAN and other serotonergic drugsIf symptoms of serotonin syndrome occurdiscontinue ZOFRAN and initiate supportive treatmentPatients should be informed of the increased risk of serotonin syndromeespecially if ZOFRAN is used concomitantly with other serotonergic drugssee DRUG INTERACTIONSOVERDOSE
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the active ingredient in zofran odt orally disintegrating tablets is ondansetron base, the racemic form of ondansetron, and a selective blocking agent of the serotonin 5-ht 3 receptor type.