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Experience with lioresal intrathecal baclofen injection obtained in parallel, placebo-controlled, randomized studies provides only a limited basis for estimating the incidence of adverse events because the studies involved a total of 62 patients exposed to a single 50 mcg intrathecal bolus.

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Patient selection is important when initiating Lioresal therapyit is likely to be of most benefit in patients whose spasticity constitutes a handicap to activities and/or physiotherapyTreatment should not be commenced until the spastic state has become stabilised.

Pump Implantation Patients should be infection-free prior to pump implantation because the presence of infection may increase the risk of surgical complicationsMoreovera systemic infection may complicate dosing.

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