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Acute interstitial nephritis has been observed in patients taking PPIs including NEXIUMAcute interstitial nephritis may occur at any point during PPI therapy and is generally attributed to an idiopathic hypersensitivity reactionDiscontinue NEXIUM if acute interstitial nephritis developssee CONTRAINDICATIONS

NEXIUM is contraindicated in patients with known hypersensitivity to substituted benzimidazoles or to any component of the formulationHypersensitivity reactions may include anaphylaxisanaphylactic shockangioedemabronchospasmacute interstitial nephritisand urticariasee ADVERSE REACTIONS

NEXIUM For Delayed-Release Oral Suspension should be administered as follows:

If you use esomeprazole for longer than 3 yearsyou could develop a vitamin B-12 deficiencyTalk to your doctor about how to manage this condition if you develop it.

Nexium can cause kidney problemsTell your doctor if you are urinating less than usualor if you have blood in your urine.

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if your illness antibiotics and requires treatment with nexium follow all directions of your doctor to achieve the greatest results.