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At 12 months, the kaplan meier estimates of the likelihood of reaching the endpoint were 10 in the viramune group, 6 in the efavirenz group, and 13 percent in the abacavir group p 0.

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The dose should not be increased to the maintenance dose until any rash has clearedIf the patient cannot switch to the full dose within four weeks of starting Viramunealternative treatments should be sought.

The prolonged-released tablets are not suitable for the initial two week phase for patients starting on Viramune and should not be used until any rash has clearedThe prolonged-release tablets have not been tested in children under three years of ageThe prolonged-release tablets must not be broken or chewed.

The Committee noted that most of the experience with Viramune was in combination with nucleoside reverse-transcriptase inhibitorsNRTIsa type of antiviral medicineand that there was insufficient evidence on the use of combination treatment including a protease inhibitoranother type of antiviral medicineafter Viramune treatmentThe Committee recommended that Viramune be given marketing authorisation.

Immediate-release tablets release the active substance immediatelyand prolonged-release tablets release it slowly over a few hourswhich allows it to be given less frequently.

The NEFA study is a controlled prospective randomised study which evaluated treatment options for patients who switch from protease inhibitorPIbased regimen with undetectable load to either Viramuneefavirenz or abacavir.

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