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Nsaids, including diclofenac, cause serious gastrointestinal gi adverse events including inflammation, bleeding, ulceration, and perforation of the esophagus, stomach, small intestine, or large intestine, which can be fatal.

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All eight NSAIDs are available on prescriptionwhile diclofenacnaproxen and ibuprofen are also available in lower dose over-the-counterOTCforms that can be obtained without a prescriptionPiroxicam is also available as an OTC topical medicine

The TGA reviews found that there is a need to raise awareness among consumers and health professionals of the cardiovascular risks associated with NSAIDs and the additional hepatotoxicity risks for diclofenacincluding OTC versions of these medicines.

In summarywhile use of NSAIDs at prescription-only dosages was already known to increase the risk of high blood pressureheart failureheart attack and strokethe TGA NSAIDs review found that these risks also applied to OTC forms of diclofenacnaproxen and ibuprofen.

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